Through out the game, the quest log will be capped to 20 many times. The guide makes use of maximizing the total amount of quests you can accept at once. Because of this it is important to follow the guide exactly and only accept quests if the guide tells you to so you won't run into issues not being able to accept a quest. If you do accept a quest that is not listed in the guide, write it down because you may need to abandon it in order to keep following the guide if your quest log is full.
I made some route changes to the Horde levels 43-44 sections. I have swapped 44 Dustwallow Marsh with 44 Desolace (the entire sections). This allowed me to do Deadmire (at lvl 43 instead of 38) and then go stop at TB to turn in Deadmire + The Black Shield at the same time, then fly quickly to do the Desolace stuff. Doing 44 Desolace is now mandatory because I think its faster with the new routes. This will also make the level 53 grind much shorter. I think these were great changes.